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Life sciences · Observational Study
ClinicalTrials.gov · October 22, 2026
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Observational Study.
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Registry record from ClinicalTrials.gov (NCT07889739). This is a study registration, not published results. Lead sponsor: Technical University of Munich. Recruitment status: RECRUITING. Study type: OBSERVATIONAL. Enrollment: 100 participants (ESTIMATED). Conditions: MDD, Severe Depression, Major Depressive Episode. Interventions: OTHER: Transcranial Magnetic Stimulation (TMS). Primary outcome measures: Correlation Between Change in Montgomery-Åsberg Depression Rating Scale (MADRS) Scores and Baseline Sensation Seeking Scale (SSS) Total Score , Baseline (within 7 days before first TMS session) to end of acute TMS course (approximately 4-6 weeks). Brief summary: his real-world observational study examines whether sensation-seeking personality traits influence the clinical response to transcranial magnetic stimulation (TMS) in patients with treatment-resistant depression (TRD). Participants will complete a validated sensation seeking scale prior to TMS treatment, and depressive symptoms will be assessed using standardized clinical scales during and after the TMS course.