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Life sciences · Phase 1 Trial
ClinicalTrials.gov · October 14, 2026
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Phase 1 Trial.
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Registry record from ClinicalTrials.gov (NCT02589522). This is a study registration, not published results. Lead sponsor: National Cancer Institute (NCI). Recruitment status: ACTIVE_NOT_RECRUITING. Phase: PHASE1. Study type: INTERVENTIONAL. Enrollment: 15 participants (ACTUAL). Conditions: Metastatic Lung Neuroendocrine Neoplasm, Metastatic Lung Non-Small Cell Carcinoma, Metastatic Lung Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain, Stage IV Lung Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8, Stage IVB Lung Cancer AJCC v8. Interventions: DRUG: Berzosertib; OTHER: Quality-of-Life Assessment; PROCEDURE: Therapeutic Conventional Surgery; RADIATION: Whole-Brain Radiotherapy. Primary outcome measures: Number of Participants With a Dose-limiting Toxicity , Up to 3 weeks after completing whole brain radiotherapy (WBRT). Brief summary: This phase I trial studies the side effects and best dose of berzosertib (M6620 \[VX-970\]) when given together with whole brain radiation therapy in treating patients with non-small cell lung cancer, small cell lung cancer, or neuroendocrine tumors that have spread from the original (primary) tumor to the brain (brain metastases). Berzosertib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Giving berzosertib together with radiation therapy may work better compared to standard of care treatment, including brain surgery and radiation therapy, in treating patients with non-small cell lung cancer, small cell lung cancer, or neuroendocrine tumors.