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Life sciences · Interventional Study
ClinicalTrials.gov · October 13, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT06976840). This is a study registration, not published results. Lead sponsor: Marta Peciña, MD PhD. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 200 participants (ESTIMATED). Conditions: Depression, Major Depressive Disorder. Interventions: DEVICE: Intermittent theta burst stimulation; DEVICE: Sham theta burst stimulation; DEVICE: Continuous theta burst stimulation. Primary outcome measures: Bold Signal Change in the Salience Network During the fMRI Experiment , Assessed at approximately day 7, day 14, and day 21 following baseline.; BOLD Signal Change in the Default Mode Network During the fMRI Experiment , Assessed at approximately day 7, day 14, and day 21 following baseline.; Changes in Mood Ratings Following TBS and the fMRI Experiment , Baseline; Subcute Mood Change Following TBS and the fMRI experiment , Approximately at day 7, 14, and 21. Brief summary: The goal of this clinical trial is to learn how different types of non-invasive brain stimulation affect mood and brain function in adults with major depressive disorder (MDD). It will also study how brain stimulation may work together with antidepressant treatments. The main questions this study aims to answer are: How do different patterns of brain stimulation affect mood in people with depression? Do brain networks involved in emotion and self-reflection respond differently depending on the type of stimulation? What are the combined effects of brain stimulation and antidepressant treatments on mood and brain activity? Researchers will compare different brain stimulation patterns and target areas to understand their individual and combined effects. Participants will: Receive three types of brain stimulation (intermittent, continuous, and sham) in different sessions Undergo MRI scans during the administration of either a fast-acting or conventional antidepressant. Complete mood assessments during the scan and for one week after each session This study may help identify brain-based strategies to improve treatment for depression. In addition, a subset of participants (\~25) will complete a reward-guided decision-making fMRI task for feasibility purposes.