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Life sciences · Observational Study
ClinicalTrials.gov · September 25, 2026
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Observational Study.
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Registry record from ClinicalTrials.gov (NCT07158086). This is a study registration, not published results. Lead sponsor: University of Zurich. Recruitment status: RECRUITING. Study type: OBSERVATIONAL. Enrollment: 500 participants (ESTIMATED). Conditions: Heart Failure, Heart Failure (for Example, Fluid Overload). Primary outcome measures: Death from any cause , From enrollment up to five years; Heart failure hospitalization , From enrollment up to five years. Brief summary: The main objective of the study is to achieve a comprehensive phenotyping of patients with heart failure, combining detailed clinical characterization with in-depth molecular profiling. By integrating clinical data with cutting-edge multi-omics techniques (including transcriptomics, epigenomics, and proteomics), this research aims to identify molecular signatures, particularly non-coding RNAs (ncRNAs), that are linked to the onset and progression of HF. Through advanced molecular profiling of biological samples and the analysis of clinical parameters, including advanced imaging, hemodynamic profiling, and biomarker analysis, the study will contribute to the deep phenotyping of HF patients. The secondary objective aims to uncover potential biomarkers that may serve as predictive indicators of disease progression and identify novel therapeutic targets, offering promising avenues for future treatments in this challenging patient population.