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Life sciences · Phase 1 Trial
ClinicalTrials.gov · October 6, 2026
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Phase 1 Trial.
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Registry record from ClinicalTrials.gov (NCT05334329). This is a study registration, not published results. Lead sponsor: University of California, Irvine. Recruitment status: ACTIVE_NOT_RECRUITING. Phase: PHASE1. Study type: INTERVENTIONAL. Enrollment: 6 participants (ACTUAL). Conditions: Advanced Lung Non-Small Cell Carcinoma, Metastatic Lung Non-Small Cell Carcinoma, Recurrent Lung Non-Small Cell Carcinoma, Refractory Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8, Stage IIIC Lung Cancer AJCC v8, Stage IV Lung Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8, Stage IVB Lung Cancer AJCC v8. Interventions: BIOLOGICAL: Antineoplastic Immune Cell; BIOLOGICAL: Atezolizumab; PROCEDURE: Biospecimen Collection; DRUG: Cyclophosphamide; DRUG: Fludarabine. Primary outcome measures: Incidence of adverse events - CTCAE , Up to 2 years; Incidence of adverse events - ASTCT , Up to 2 years; Dose limiting toxicities , Within 28 days of the first COH06 infusion. Brief summary: This phase I trial studies the side effects and best dose of COH06 with or without atezolizumab in patients with non-small cell lung cancer previously treated with PD-1 and/or PD-L1 immune checkpoint inhibitors that has spread to other places in the body (advanced) and that has not responded to previous treatment (refractory). NK cells are infection fighting blood cells that can kill tumor cells. The NK cells given in this study, COH06, will come from umbilical cord blood and will have a new gene put in them that makes them express PD-L1, and express and secrete IL-15. NK cells that express PD-L1 may kill more tumor cells, and IL-15 may allow the NK cells to live longer. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving COH06 without or without atezolizumab may help control the disease in patients with non-small cell lung cancer.