Loading
Life sciences · Journal article
Revista Española De Quimioterapia · September 8, 2026
A consensus or society position rather than new primary data.
PRECISE is a mnemonic-based stewardship framework consisting of seven sequential clinical steps (Pathogen assessment, Resistance phenotype interpretation, Evaluate MIC, Curtail spectrum, Individualize PK/PD, Switch route, and Endpoint optimization) designed to standardize antibiogram interpretation and guide de-escalation decisions at the bedside. The source presents the framework conceptually and illustrates its application through three clinical vignettes, but does not report empirical validation, outcome comparison, or efficacy data.
Journal article. Clinicians prescribing antimicrobials, particularly those without infectious-disease training; patients receiving antimicrobial therapy.
Empiric therapy aligned with guidelines is associated with mortality reduction of roughly one-third De-escalation on the basis of culture results is associated with mortality reduction of more than half Antibiogram documents are often read superficially or misinterpreted, particularly by non-infectious-disease clinicians
Empiric therapy aligned with guidelines is associated with mortality reduction of roughly one-third De-escalation on the basis of culture results is associated with mortality reduction of more than half
Clinicians should consider adopting the PRECISE framework to systematize antibiogram interpretation and guide de-escalation decisions, which the source indicates may substantially reduce mortality. However, the framework has not been empirically validated; its impact on clinical outcomes or prescribing accuracy remains unknown.
A structured clinical framework (mnemonic tool) designed to guide antibiogram interpretation and antimicrobial de-escalation at the bedside, intended to reduce misinterpretation by non-specialist clinicians.
Quoted from the source exactly as published.
Clinicians should consider adopting the PRECISE framework to systematize antibiogram interpretation and guide de-escalation decisions, which the source indicates may substantially reduce mortality. However, the framework has not been empirically validated; its impact on clinical outcomes or prescribing accuracy remains unknown.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Antimicrobial resistance claimed an estimated 4.95 million lives in 2019. When clinicians prescribe empiric therapy that follows guidelines, mortality drops by roughly a third; when they de-escalate on the basis of culture results, it drops by more than half. Yet the document that should drive both decisions, the antibiogram, is often read superficially or misinterpreted, particularly by physicians without infectious-disease training. Existing stewardship frameworks address prescribing principles, timing, or ecological impact, but none walks the clinician step by step through an individual susceptibility report and out the other side with a treatment plan. PRECISE is a seven-step mnemonic designed for that purpose. Each letter corresponds to a clinical action: Pathogen assessment, Resistance phenotype interpretation, Evaluate MIC, Curtail spectrum, Individualize PK/PD, Switch route, and Endpoint optimization. Three clinical vignettes (including one in which the steps deliberately collide) illustrate how the framework operates in practice.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.