Life sciences · Observational Study
ClinicalTrials.gov · September 22, 2026
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Observational Study.
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Registry record from ClinicalTrials.gov (NCT04000061). This is a study registration, not published results. Lead sponsor: University Hospital, Basel, Switzerland. Recruitment status: RECRUITING. Study type: OBSERVATIONAL. Enrollment: 6000 participants (ESTIMATED). Conditions: Acute Heart Failure, Acute Coronary Syndrome. Interventions: OTHER: medical chart review; OTHER: data generated by direct IT export. Primary outcome measures: number of all-cause death , 1 to 8 years after hospitalization; number of HF hospitalizations , 1 to 8 years after hospitalization; number of cardiovascular death , 1 to 8 years after hospitalization; number of cardiovascular hospitalizations , 1 to 8 years after hospitalization. Brief summary: This retrospective cohort study is to identify triggers of heart failure (HF) development and drivers of HF progression as well as the underlying cardiac disease (phenotype) to identify patients at risk and predict the clinical course of the disease. Data of patients who were hospitalized during the years 2010-2023 with acute coronary syndrome (ACS) and/ or with acute heart failure (AHF) will be collected and analyzed. In a subgroup cohort efficacy and safety of digoxin in patients with acute heart failure triggered by tachyarrhythmia will be evaluated.