Life sciences · Phase 2 Trial
ClinicalTrials.gov · October 21, 2026
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Phase 2 Trial.
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Registry record from ClinicalTrials.gov (NCT06502977). This is a study registration, not published results. Lead sponsor: Amgen. Recruitment status: ACTIVE_NOT_RECRUITING. Phase: PHASE2. Study type: INTERVENTIONAL. Enrollment: 32 participants (ACTUAL). Conditions: Extensive Stage Small Cell Lung Cancer. Interventions: DRUG: Tarlatamab. Primary outcome measures: Objective Response Rate (ORR) Based on Blinded Independent Central Review (BICR) Per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) , From first dose of trial drug up to a minimum of last dose + 65 days or data cutoff date; median (min, max) time on trial was 3.4 (2.2, 6.5) months at data cut off. Brief summary: The primary aim of this study is to evaluate the efficacy of tarlatamab as assessed by objective response rate (ORR) based on blinded independent central review (BICR) per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1).