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Life sciences · Interventional Study
ClinicalTrials.gov · November 9, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07925047). This is a study registration, not published results. Lead sponsor: Beijing HuiLongGuan Hospital. Recruitment status: NOT_YET_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 70 participants (ESTIMATED). Conditions: Major Depressive Disorder (MDD. Interventions: DEVICE: Active Temporal Interference Stimulation; DEVICE: Sham Temporal Interference Stimulation. Primary outcome measures: Hamilton Depression Rating Scale (HAMD-24) , Baseline, immediately after the intervention, and at 1-week and 4-week follow-ups; Snaith-Hamilton Pleasure Scale (SHAPS) , Baseline, immediately after the intervention, and at 1-week and 4-week follow-ups; Probabilistic Reversal Learning (PRL) Task , Baseline, immediately after the intervention, and at 1-week and 4-week follow-ups. Brief summary: This study aims to investigate the effects and neural mechanisms of individualized temporal interference stimulation (TI) targeting the left nucleus accumbens in older adults with depression. A total of 70 participants aged 60-80 years will be randomly assigned to receive active TI or sham stimulation. Clinical and cognitive assessments, a probabilistic reversal learning (PRL) task, MRI, and TMS-EEG will be used to evaluate changes in depressive symptoms, reward processing, and brain activity. Clinical and cognitive follow-up assessments will be conducted at 1 and 4 weeks after the intervention.