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Life sciences · Interventional Study
ClinicalTrials.gov · October 21, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT05978804). This is a study registration, not published results. Lead sponsor: Johns Hopkins University. Recruitment status: TERMINATED. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 5 participants (ACTUAL). Conditions: Mild Cognitive Impairment, Primary Progressive Aphasia, Dementia. Interventions: OTHER: Computerized Cognitive Training; DEVICE: Active tDCS (tDCS) on DLPFC. Primary outcome measures: Change in Language Composite Outcome , Up to 6 weeks before intervention (before Phase 1) up to 1 week post-intervention (after Phase 1). Phase 1 intervention lasted 10 weeks.; Change in Executive Composite Outcome , Up to 6 weeks before intervention (before Phase 1) up to 1 week post-intervention (after Phase 1). Phase 1 intervention lasted 10 weeks.; Change in Global Cognitive Scores , Up to 6 weeks before intervention (before Phase 1) up to 1 week post-intervention (after Phase 1). Phase 1 intervention lasted 10 weeks.. Brief summary: The primary objective of this research is to evaluate the effects of non-invasive brain stimulation and computerized cognitive training on executive functioning in individuals with Primary Progressive Aphasia (PPA), mild cognitive impairment (MCI), or dementia. In this study, investigators will use transcranial direct current stimulation (tDCS) to stimulate the left dorsolateral prefrontal cortex (DLPFC). Previous studies have demonstrated that tDCS over the DLPFC led to improvements in attention deficit caused by stroke, Parkinson's Disease, and major depression as well as language deficits caused by neurodegenerative conditions such as primary progressive aphasia or mild cognitive impairment. The investigators seek to expand on this literature by investigating how anodal tDCS paired with and without cognitive training will impact executive functioning in PPA with Frontotemporal Dementia or Alzheimer's Disease pathology and Mild Cognitive Impairment/Alzheimer's Disease (e.g. shifting, updating, monitoring, and manipulation).