Loading
Life sciences · Preprint
arXiv · September 24, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Preprint.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
This record has not been graded across any dimension yet. Treat the label above as provisional and read the source.
What is missing. This record has no bottom line, key findings, reported figures, evidence dimensions. That is a gap in the analysis, not a judgement about the study.
Fine-tuning large language models on new objectives can improve helpfulness, instruction following, or domain-specific performance, but it can also induce regressions on safety-critical prompts. Existing safety-preserving fine-tuning methods typically control average safety loss or use weighted auxiliary penalties, which can obscure rare but severe failures. We propose a chance-constrained formulation for safety-preserving fine-tuning that limits the fraction of safety examples whose degradation relative to a reference model exceeds a prescribed threshold. Because the resulting empirical chance constraint contains a discontinuous indicator, we introduce a differentiable majorization of the violation rate, yielding a tractable conservative constraint. We then develop a constraint-aware gradient descent method that treats the majorized constraint as a safe set in parameter space and minimally modifies the fine-tuning direction to preserve feasibility. The resulting update admits a closed form and produces a tail-aware safety correction that emphasizes examples near or above the degradation threshold. We conduct an extensive set of experiments on harmful fine-tuning across three different tasks and three models and show that our approach consistently outperforms the baselines that exist in the literature. These results suggest that safety preservation in LLM fine-tuning is better viewed as a reliability-constrained optimization problem than as average-risk regularization.