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Life sciences · Interventional Study
ClinicalTrials.gov · October 22, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT04042532). This is a study registration, not published results. Lead sponsor: Chang Gung Memorial Hospital. Recruitment status: COMPLETED. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 30 participants (ACTUAL). Conditions: Alzheimer Disease, Early Onset. Interventions: DEVICE: Theta-burst stimulation (TBS). Primary outcome measures: Change from baseline MMSE total scores immediately after TBS intervention , Before and immediately after TBS intervention; Change from baseline MMSE total scores 4 weeks after TBS intervention , Before and 4 weeks after TBS intervention; Change from baseline ADAS-Cog total scores immediately after TBS intervention , Before and immediately after TBS intervention; Change from baseline ADAS-Cog total scores 4 weeks after TBS intervention , Before and 4 weeks after TBS intervention. Brief summary: Young-onset dementia (YOD) is a devastating condition, and it produces substantial psychosocial impacts on individual's functioning and family's care burden. Alzheimer's disease (AD) dementia is the most common type in YOD. Medication treatment Response was limited and unsatisfactory. In recent years, repetitive transcranial magnetic stimulation (rTMS) has been considered an alternative for the improvement of cognition in older patients with cognitive impairment. This study aims to examine the effects and potential mechanisms of theta-burst stimulation (TBS) on cognitive function in individuals with young-onset AD.