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Life sciences · Review
Quality in Sport · August 8, 2026
A consensus or society position rather than new primary data.
This narrative review concludes that high-protein diets are effective for short- and medium-term weight management through increased satiety, thermogenesis, and fat-free mass preservation, with particular benefit in obesity and type 2 diabetes. However, long-term safety concerns exist regarding renal workload, nephrolithiasis, hyperuricemia, and nutritional deficiencies—especially with animal sources—and evidence on cancer risk remains inconclusive. The authors recommend individualized dietary planning pending further long-term studies.
Narrative review. Individuals with obesity, insulin resistance, or type 2 diabetes; general population using high-protein diets for weight reduction and body composition improvement.. Intervention: High-protein diets.
High-protein diets promote weight loss by increasing satiety, thermogenesis, energy expenditure, and preserving fat-free mass. Benefits are particularly evident in individuals with obesity, insulin resistance, or type 2 diabetes. Excessive long-term intake, especially from animal sources, may increase renal workload, nephrolithiasis, hyperuricemia, and nutritional deficiencies.
Long-term safety data and cancer risk remain inconclusive per the authors.
Clinicians should counsel patients that high-protein diets are effective for short- to medium-term weight management and metabolic improvement, particularly in metabolic disease, but should individualize protein source, total intake, and overall dietary quality and monitor long-term safety, especially in those at risk for renal disease. Further long-term evidence is needed to establish definitive guidelines.
A narrative review synthesizing evidence on high-protein diet mechanisms and clinical effects, offering recommendations for appropriate use but acknowledging gaps requiring further research.
As stated by the source record.
Clinicians should counsel patients that high-protein diets are effective for short- to medium-term weight management and metabolic improvement, particularly in metabolic disease, but should individualize protein source, total intake, and overall dietary quality and monitor long-term safety, especially in those at risk for renal disease. Further long-term evidence is needed to establish definitive guidelines.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no reported figures. That is a gap in the analysis, not a judgement about the study.
Background: High-protein diets are widely used for weight reduction, body composition improvement, and metabolic health. Although effective, concerns remain regarding their long-term safety. This review summarizes current evidence on their benefits and risks. Materials and methods: A narrative review of randomized controlled trials, systematic reviews, meta-analyses, and observational studies evaluated the effects of high-protein diets on metabolic health and potential adverse outcomes. Results: High-protein diets promote weight loss by increasing satiety, thermogenesis, energy expenditure, and preserving fat-free mass. They improve appetite regulation through increased GLP-1 and GIP secretion and reduced ghrelin levels. Benefits are particularly evident in individuals with obesity, insulin resistance, or type 2 diabetes. However, excessive long-term intake, especially from animal sources, may increase renal workload, nephrolithiasis, hyperuricemia, nutritional deficiencies, and possibly cardiovascular risk. Evidence regarding cancer remains inconclusive. Conclusions: When appropriately planned and individualized, high-protein diets are effective for short- and medium-term weight management. Their long-term safety depends on protein source, dietary quality, and individual health status. Further long-term studies are needed to define their role in clinical practice.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.