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Life sciences · Interventional Study
ClinicalTrials.gov · October 28, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT06511544). This is a study registration, not published results. Lead sponsor: Indiana University. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 20 participants (ESTIMATED). Conditions: Depression, Treatment Resistant. Interventions: DEVICE: Transcranial magnetic stimulation. Primary outcome measures: Functional Connectivity , Before Transcranial magnetic stimulation (TMS) - immediately following TMS; Rumination , Before TMS- immediately following TMS. Brief summary: The goal of this clinical trial is to learn if Transcranial Magnetic Stimulation (TMS) to part of the brain called the ventromedial prefrontal cortex (VMPFC) can treat a symptom called rumination in adults with major depression that has not responded to at least one medication trial. The main question it aims to answer are: Does TMS to the VMPFC change brain activity on functional magnetic resonance imaging (fMRI) during a negative self-referential processing task in adults with depression? Does TMS to the VMPFC affect rumination in adults with depression? Researchers will compare brain scans and rumination scores before, during, and immediately after TMS. Participants will: Undergo three functional MRI scans Undergo a course of 20 TMS treatments Respond to clinical questionnaires and complete a computer behavioral task