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Life sciences · Interventional Study
ClinicalTrials.gov · October 15, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT05938543). This is a study registration, not published results. Lead sponsor: Brigham and Women's Hospital. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 20 participants (ESTIMATED). Conditions: Prader-Willi Syndrome. Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation (rTMS). Primary outcome measures: Retention of subjects in study assessments , 1-week post-TMS follow-up visit; Time required to enroll subjects into study , At study completion, up to 18 months; Change in BOLD response , baseline, 1-week post-TMS follow-up visit. Brief summary: This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study hyperphagia and satiety in Prader-Willi syndrome. TMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the brain. The magnetic field is produced by a coil that is held next to the scalp. In this study, the investigators will be stimulating the brain to learn more about how TMS might improve hyperphagia in Prader-Willi syndrome.