Life sciences · Preprint
arXiv · September 23, 2026
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Collective responses depend on individual differences, contact opportunities, and accumulated experience. Learning their dynamics from aggregate counts requires connecting a population's response distribution to both current observations and future behavior. We introduce Differentiable Gaussian Dynamics (DGD), which learns this connection through three components: a Gaussian mixture representing heterogeneous response propensities, differentiable aggregation of contact intensity and behavioral probabilities, and feedback recurrence that updates subsequent responses. Reparameterized integration and temporal recurrence let aggregate prediction errors jointly train the distribution, observation functions, and feedback parameters. On four windows from KuaiRand-Pure and Online Retail II, DGD achieves lower joint behavioral negative log-likelihood than a DeepAR adaptation with a joint-behavior head. In Retail 2010, its one-day behavioral-count MAE is 4.71 versus 6.88 for this adaptation. Learning the distribution reduces behavioral negative log-likelihood by 10.82% relative to a fixed Gaussian in KuaiRand's standard-recommendation window; removing feedback dynamics raises joint KL from 0.0340 to 0.2577 in a controlled experiment. These results establish the value of learning population representations and their feedback process from aggregate observations. Code is available at https://github.com/OranAi-Ltd/oransim.