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Life sciences · Interventional Study
ClinicalTrials.gov · October 14, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT05783765). This is a study registration, not published results. Lead sponsor: University of Pennsylvania. Recruitment status: ACTIVE_NOT_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 317 participants (ACTUAL). Conditions: Obesity, Childhood. Interventions: BEHAVIORAL: Heightened Drive to Eat. Primary outcome measures: Body Mass Index (BMI) , Change from baseline to 1-year follow-up; Waist circumference , Change from baseline to 1-year follow-up; Body fat , Change from baseline to 1-year follow-up. Brief summary: A genetic risk for obesity does not always translate to the development of obesity among children, which points to the presence of risk-modifying factors that likely relate to energy balance behaviors as key behavioral drivers. Using an integrated approach to comprehensively examine the interplay between genotype and phenotype, this study will systematically assess the extent to which energy balance behaviors, alone or in combination, in conjunction with family-level influences can modify behavioral and genetic predispositions to childhood obesity in a high-risk sample of predominantly minority children from low-resource backgrounds. Identifying protective factors that may mitigate the impact of obesity risk on weight and adiposity outcomes is critical for moving the prevention of childhood obesity into a new direction.