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Life sciences · Preprint
arXiv · October 14, 2026
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MeanFlow predicts interval-average velocities, but conventional few-step sampling ties the interval queried from the model to the duration of the state update. We separate these two quantities at inference, fixing the model, update grid, and number of queries while varying the prediction horizon. Our central finding is that the horizon response depends on both query position and the states entering that query. Across seven independently trained CIFAR-10 checkpoints at classifier-free guidance (CFG) scale 2, a longer horizon worsens FID at early steps but improves it at the midpoint. To probe whether query time alone determines this response, we fix the midpoint query and current/subsequent guidance while changing only earlier CFG. In held-out factorial outcomes on five previously studied checkpoints, the mean midpoint horizon benefit increases from 0.109 to 1.308 FID, indicating sensitivity to the incoming-state distribution. A frozen four-query rule reduces mean CIFAR-10 FID by 2.023 without retraining or extra queries, including gains on five checkpoints trained after rule selection. A milder rule also improves mean FID by 1.041 on a stronger frozen grid, with fixed-rule FID gains on the evaluated public ImageNet-256 and AFHQ checkpoints. However, matched-budget calibration favors query-start shifting in historical CIFAR tests, and the tested Horizon allocation adds no FID benefit beyond Grid+Start on two public ImageNet models. Thus, prediction horizon is a distinct, position- and state-sensitive inference control, but not a universally preferred one.