Loading
Life sciences · Journal article
Acs Omega · October 19, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Journal article.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
This record has not been graded across any dimension yet. Treat the label above as provisional and read the source.
What is missing. This record has no bottom line, key findings, reported figures, evidence dimensions. That is a gap in the analysis, not a judgement about the study.
Abstract Prostate cancer remains one of the leading causes of cancer-related death among men worldwide. Photodynamic therapy (PDT) has emerged as a promising strategy to enhance conventional treatments, yet its efficacy is often limited by poor solubility, instability, and a lack of targeting of photosensitizers. Here, we report the development of hybrid erythrosine–iron oxide nanoemulsions (MNE/Ery) produced by vacuum-assisted nanoemulsification. The optimized formulation (0.05 mg·mL–1 erythrosine; 0.5 mg·mL–1 maghemite) exhibited a hydrodynamic diameter of ∼100 nm, negative surface charge, and strong retention of the photosensitizer’s spectral profile. The iron oxide nanoparticles (20–30 nm) exhibited efficient magnetic heating potential, reaching 42 °C within 5.5 min under an alternating field (418 kHz, 12 kA·m–1), indicating suitability for future exploration in magnetic hyperthermia applications. While MNE/Ery maintained high biocompatibility toward healthy cells (HDFn and PNT2), it induced a potent light-triggered cytotoxic response in PC-3 prostate cancer cells. Upon irradiation, the platform delivered a robust, dose-dependent therapeutic effect even at conservative fluences, driven by the combination of maghemite-induced oxidative stress (ferroptosis) and erythrosine-mediated ROS generation. These findings position the MNE/Ery system as a promising nanotechnological platform for PDT with an intrinsic iron-mediated chemotherapeutic effect, with additional potential for future magnetic hyperthermia-based applications.