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Life sciences · Interventional Study
ClinicalTrials.gov · September 25, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT05888961). This is a study registration, not published results. Lead sponsor: Centre Hospitalier Universitaire Dijon. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 74 participants (ESTIMATED). Conditions: Cognitive Disorders. Interventions: BIOLOGICAL: Blood samples; OTHER: Interviewing the subject and scales; OTHER: Neurocognitive evaluation; OTHER: Taste tests; OTHER: Computerized food preference questionnaires; OTHER: Nutritional status - body composition. Primary outcome measures: Amplitude of the gustatory evoked potentials , After a 2-hour fasting period; Gustatory evoked potentials latency , After a 2-hour fasting period. Brief summary: The aim of the MAPEG 2 study is to explore gustatory function and to follow its evolution in the 4 following groups of participants: * Healthy subjects * Participants with isolated cognitive complaint * Participants with minor neurocognitive disorder * Participants with mild and moderate Alzheimer-type major neurocognitive disorders For this purpose, we want to compare the results of the following tests: * Subjective taste tests (tasting solutions, answering food preference questionnaires), * Gustatory evoked potential (GEP) parameters, recorded by electrodes placed on the scalp, * And nutritional parameters (hormones of food intake by blood test, measurement of the global body composition). Identifying and following the evolution of early taste disorders in case of cognitive disorders could improve the diagnosis of Alzheimer\'s disease in two ways: * To allow an early diagnosis of Alzheimer\'s disease, and thus improve its management, * To define groups of subjects at risk of developing Alzheimer\'s disease in later years.