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Life sciences · Journal article
Meditsinskiy Sovet = Medical Council · September 22, 2026
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Introduction. The prevalence of excess body weight has reached epidemic proportions. The “obesity paradox” is a well-known phenomenon, but some aspects of the pathogenesis of associated cardiorenal-metabolic disorders remain unclear. A comprehensive study assessing the condition of the endothelium, cardiovascular system, and kidneys in overweight individuals is advisable. Aim. To characterize the state of the endothelium, cardiovascular system and kidneys in overweight patients by studying biomarkers of endothelial, cardiac and renal dysfunction, and 24-hour blood pressure monitoring. Materials and methods. The cross-sectional study included 88 participants divided into two groups: a study group of 58 overweight patients and a comparison group of 30 normal-weight participants. In these groups, concentrations of routine blood biochemical parameters (creatinine, urea), markers of endothelial dysfunction (endothelin-1, fibroblast growth factor-23, von Willebrand factor, and total antioxidant status), myocardial dysfunction (N-terminal pro-B-type brain natriuretic peptide), and renal dysfunction (cystatin C), and 24-hour blood pressure monitoring parameters, were determined and analyzed. Results. Overweight patients showed a significant (p < 0.05) increase in the magnitude and rate of the morning rise in systolic blood pressure. Creatinine and urea concentrations in the study group were significantly (p < 0.05) higher than in the comparison group. Overweight patients had higher levels of the N-terminal fragment of pro-B-type brain natriuretic peptide and total serum antioxidant status (p = 0.001). Positive correlations were found between body mass index and creatinine, cystatin C, N-terminal fragment of pro-B-type brain natriuretic peptide, von Willebrand factor, and total serum antioxidant status. Conclusion. Excess body weight is associated with complex, functionally interconnected subclinical damage to the endothelium, heart, and kidneys. Long-term studies are needed to capture the dynamics of cardiorenal-metabolic disorders in overweight patients.