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Life sciences · Interventional Study
ClinicalTrials.gov · September 14, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT05574634). This is a study registration, not published results. Lead sponsor: Virginia Polytechnic Institute and State University. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 200 participants (ESTIMATED). Conditions: Aging, Alzheimer Disease. Interventions: BEHAVIORAL: Tablet based adaptive multimodal attention practice program; BEHAVIORAL: Tablet based adaptive criterion task practice program. Primary outcome measures: Change in accuracy on the place-face selective attention task after two weeks , Scan before and after attentional practice (2 weeks between scans); Change in fMRI LC-SN connectivity after two weeks , Scan before and after attentional practice (2 weeks between scans). Brief summary: A growing body of research has highlighted the importance of frontal regions, at both the functional and structural levels, in age-related declines in attentional and cognitive processing. However, the underlying neurobiological pathophysiological changes in the brain that contribute to these declines are still largely unclear. The objective of this proposal is to investigate neural mechanisms of age-related attentional distractibility, focusing on the neural circuit initiated from the locus coeruleus (LC). In the current proposal, the investigators will test the hypothesis that the neural disconnectivity of LC with the salience network (SN) drives failures of ignoring distractors in older adults. The investigators will examine how LC-SN connectivity is associated with selective attention performance, and how improved LC-SN connectivity through a cognitive training program may lead to improved attentional performance.