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Life sciences · Interventional Study
ClinicalTrials.gov · November 6, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07300332). This is a study registration, not published results. Lead sponsor: University of Thessaly. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 30 participants (ESTIMATED). Conditions: Obesity & Overweight, Vitamin D. Interventions: OTHER: Exercise training; OTHER: Control. Primary outcome measures: Change in 25-hydroxyvitamin D concentration , At baseline, 6 weeks and 12 weeks; Change in plasma Vitamin D binding protein concentration , At baseline, 6 weeks and 12 weeks; Change in calcium concentration , At baseline, 6 weeks and 12 weeks; Change in albumin concentration , At baseline, 6 weeks and 12 weeks; Change in aspartate aminotransferase (SGOT) concentration , At baseline, 6 weeks and 12 weeks; Change in alanine aminotransferase (SGPT) concentration , At baseline, 6 weeks and 12 weeks; Change in gamma-glutamyl transferase (γ-GT) concentration , At baseline, 6 weeks and 12 weeks. Brief summary: The prevalence of Vitamin D deficiency is significantly higher in adults with overweight/obesity compared to those with normal body mass index (BMI). The "entrapment" of Vitamin D in adipose tissue due to impaired lipolytic stimulation and/or adipose tissue dysfunction has been proposed as the driving mechanism. Exercise training has been proposed as a promising strategy to increase mobilization of Vitamin D from adipose tissue, given its well described role in stimulating lipolysis. Indeed, a recent study revealed that participation in moderate-intensity cardiovascular type exercise over winter can mitigate the decline in 25-hydroxyvitamin D \[25(OH)D\] in adults with overweight/obesity, independent of weight loss. The aim of this study is to investigate the impact of hybrid-type high-intensity interval training over winter on vitamin D metabolism, in adults with overweight/obesity.