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Life sciences · Interventional Study
ClinicalTrials.gov · September 21, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT04494074). This is a study registration, not published results. Lead sponsor: Centre Hospitalier Intercommunal Creteil. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 820 participants (ESTIMATED). Conditions: Septic Shock. Interventions: OTHER: External Cooling. Primary outcome measures: Mortality , Day 60 from randomization. Brief summary: The best strategy for managing fever in patients with septic shock remains unknown. In a pilot study, the investigators showed that fever control at normothermia allowed a better control of shock and evolution of organ failures. In this second trial the investigators will conduct a multicentre, open-label, randomized controlled, superiority trial in which two strategies will be compared: 1. Respect of fever 2. Fever control at normothermia using external cooling The primary end point will be d-60 mortality.