Life sciences · Observational Study
ClinicalTrials.gov · September 25, 2026
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Observational Study.
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Registry record from ClinicalTrials.gov (NCT07841249). This is a study registration, not published results. Lead sponsor: Tongji Hospital. Recruitment status: RECRUITING. Study type: OBSERVATIONAL. Enrollment: 604 participants (ESTIMATED). Conditions: Lung Cancer (NSCLC). Interventions: PROCEDURE: Lobectomy; PROCEDURE: Sublobar Resection. Primary outcome measures: Change in peak oxygen uptake (peak VO2) , Baseline and at 6 and 12 months after surgery; Change in maximum oxygen uptake per kilogram of body weight , Baseline and at 6 and 12 months after surgery; Change in maximum oxygen uptake as a percentage of the predicted value , Baseline and at 6 and 12 months after surgery; Change in anaerobic threshold (AT) , Baseline and at 6 and 12 months after surgery. Brief summary: This observational study will compare changes in cardiorespiratory fitness after lobectomy and sublobar resection. Sublobar resection includes segmentectomy and wedge resection. Patients who can undergo pulmonary resection and meet the eligibility criteria will be studied during routine clinical care; the research will not assign the surgical procedure or add a study-specific intervention. Cardiopulmonary exercise testing (CPET) and pulmonary function testing will be performed before surgery and at routine follow-up visits 6 and 12 months after surgery. Changes from the preoperative assessment will be compared within each surgical group and between the two groups. The study will also examine the relationship between CPET measurements and postoperative complications.