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Life sciences · Journal article
Lwt · August 1, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a descriptive genomic epidemiological survey integrating whole-genome sequencing data from over 146,000 Campylobacter strains to characterize the global prevalence and phylogenetic distribution of the blaOXA resistance gene family. The study identifies blaOXA-193 as predominant and documents association of resistance genes with dominant clonal complexes (CC-21, CC-828) and sequence type ST-50 across food, clinical, and environmental sources, suggesting potential for cross-border dissemination. However, the analysis does not establish clinical impact, quantify transmission risk, or demonstrate causal links between clonal spread and actual resistance phenotypes or treatment failure.
Retrospective genomic epidemiological survey using whole-genome sequencing and multilocus sequence typing. Campylobacter strains with documented antimicrobial resistance phenotypes isolated globally from food, clinical, and environmental sources across multiple time periods. n = 146,267. Global; 146,253 strains from GenBank database plus 14 strains from China.
Analysis integrated WGS data from 146,253 global Campylobacter strains with valid AMR information plus 14 indigenous Chinese strains blaOXA-193 identified as the predominant subtype among blaOXA gene family members Clonal complexes CC-21 and CC-828 identified as global dominant drivers of cross-border blaOXA dissemination
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This survey documents the widespread distribution and phylogenetic structure of a β-lactam resistance gene in Campylobacter but does not demonstrate clinical consequences or quantify the risk of resistance-associated treatment failure. Clinicians should interpret the findings as evidence of a public health surveillance concern requiring continued monitoring rather than immediate changes to treatment practice.
Large-scale genomic epidemiological survey describing prevalence and phylogenetic patterns of a resistance gene, but lacks clinical outcomes, intervention, or mechanistic evidence of transmission risk.
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Quoted from the source exactly as published.
This survey documents the widespread distribution and phylogenetic structure of a β-lactam resistance gene in Campylobacter but does not demonstrate clinical consequences or quantify the risk of resistance-associated treatment failure. Clinicians should interpret the findings as evidence of a public health surveillance concern requiring continued monitoring rather than immediate changes to treatment practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Campylobacter is recognized as a critical global foodborne pathogen, and the widely prevalent bla OXA gene family within its population is a key determinant of resistance to β-lactam antibiotics. To elucidate its global epidemiological characteristics and transmission dynamics, this study integrated whole genome sequencing (WGS) data from 146,253 global Campylobacter strains with valid antimicrobial resistance (AMR) information from the GenBank database and 14 indigenous strains sequenced in China. Whole-genome analysis revealed an extremely high overall prevalence of bla OXA genes, with bla OXA-193 identified as the predominant subtype. Multilocus sequence typing (MLST) indicated that the global dominant clonal complexes CC-21 and CC-828 drove the cross-border dissemination of bla OXA genes, while ST-50 emerged as the major dominant sequence type. Based on isolation time, country, and source, whole-genome multilocus sequence typing (wgMLST) analysis further confirmed close phylogenetic associations among bla OXA -positive strains from diverse global regions and sources. Global dissemination is fueled by dominant clones and regional expansion. In conclusion, this study provides the first large-scale genomic epidemiological analysis of bla OXA genes in Campylobacter. The close association observed among positive strains isolated from food, clinical, and environmental sources highlights the public health risk of zoonotic transmission of these high-risk clones.
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