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Life sciences · Journal article
Mikrobiyoloji Bulteni · July 30, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is an in vitro screening study examining ethanolic and methanolic extracts of Taraxacum officinale parts against clinical multidrug-resistant bacterial isolates using diffusion assays. Mean inhibition zones ranged from 6.0–8.0 mm (disc) to 8.0–20.6 mm (agar well), with greatest activity against S. aureus and Enterococcus spp., and phenolic and flavonoid content measured in leaf extracts. The authors themselves label this as preliminary data; it is exploratory work establishing whether herbal extracts warrant further investigation, not evidence of clinical utility.
In vitro uncontrolled antibacterial diffusion assay with antioxidant assay. Bacterial isolates (S. aureus, Enterococcus faecalis, Enterococcus faecium, E. coli, P. aeruginosa) obtained from clinical samples; isolates exhibited various resistance patterns and caused hospital-acquired infections.. Intervention: Ethanolic and methanolic extracts of Taraxacum officinale (leaf, flower, root) prepared via Soxhlet extraction.
Mean inhibition zone diameters ranged 6.0–8.0 mm in disc diffusion and 8.0–20.6 mm in agar well diffusion methods. Antibacterial activity was most pronounced against S. aureus isolates; inhibition zones against Enterococcus spp. were larger than against other bacteria tested. Ethanolic and methanolic flower extracts showed higher antibacterial activity than leaf and root extracts.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
This is preliminary laboratory evidence only. Clinicians should not consider these findings indicative of efficacy for treating resistant infections in patients; substantial additional work including pharmacokinetic, toxicity, and in vivo efficacy studies would be required before clinical trials.
In vitro testing of herbal extracts against clinical bacterial isolates with modest inhibition zones and no comparison to standard antibiotics or positive controls; early-stage work requiring confirmation in relevant infection models.
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Quoted from the source exactly as published.
This is preliminary laboratory evidence only. Clinicians should not consider these findings indicative of efficacy for treating resistant infections in patients; substantial additional work including pharmacokinetic, toxicity, and in vivo efficacy studies would be required before clinical trials.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
The rise in antibiotic-resistant microorganisms poses challenges in treating infectious diseases. It is known that Taraxacum officinale (dandelion) extracts have antimicrobial effects. This study aimed to investigate the antibacterial activities of different parts of T.officinale extracted through the Soxhlet device, against bacteria with various resistance patterns that cause hospital-acquired infections. The antibacterial effects of ethanolic and methanolic extracts were tested against Staphylococcus aureus, Enterococcus spp. (Enterococcus faecalis and Enterococcus faecium), Escherichia coli and Pseudomonas aeruginosa isolates obtained from clinical samples using disc and agar well diffusion methods. Besides, the total phenolic (TPC) and flavonoid contents (TFC) of the extracts, as well as their total antioxidant capacities (TAC), were evaluated in relation to their antibacterial activities. Mean inhibition zone diameters produced by extracts ranged between 6.0-8.0 mm in the disc diffusion method and 8.0-20.6 mm in the agar well diffusion method. Antibacterial activity was more pronounced particularly against S.aureus isolates. However, inhibition zone diameters against Enterococcus spp. isolates were found to be larger compared to those against other bacteria. Ethanolic and methanolic flower extracts had higher antibacterial activity on the isolates compared to leaf and root extracts. However, the TPC, TFC, and TAC values of ethanolic leaf extracts were higher than those of the other extracts, with values of 78.09 ± 1.13 mg GAE/g extract DW, 197.20 ± 6.22 mg QE/g extract DW, and 2.65 ± 0.03 µg AAE/mL extract, respectively.This study presents preliminary data on the antibacterial potential of herbal extracts against infections caused by resistant isolates.
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