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Debing Wang

Zhejiang Center for Disease Control and Prevention

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AUG 7, 2026 · JOURNAL ARTICLE

Insulin resistance as a potential mediator between central obesity and diabetic kidney disease risk in type 2 diabetes

Scientific Reports

Cross-sectional study with a large community sample demonstrating that central obesity associates with DKD risk via insulin resistance as a partial mediator, but causality cannot be inferred and the effect is attenuated by metabolic adjustment.

PromisingLi Xie Yu Dong Mei Lu

Reported

Sample size4674

DKD prevalence overall52.439%

DKD prevalence in IR group60.046%

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