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Rishika Dhapola

Advanced Pharmacology and Neuroscience Laboratory, Department of Pharmacology, School of Health Sciences, Central University of Punjab, Bathinda 151401, Punjab, India.

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MAY 27, 2026 · JOURNAL ARTICLE

Evaluation of the neuroprotective effects of ergosterol in a streptozotocin-induced Alzheimer's disease rat model: Insights into anti-inflammatory and antioxidant mechanisms.

Experimental Neurology

Animal model study with in-silico support showing ergosterol reduces oxidative stress and neuroinflammation in STZ-induced rat AD; no human data, mechanistic insight only, and lacks quantified effect sizes with confidence intervals.

PreliminaryDibbanti HariKrishnaReddy Alzheimer Disease Disease Models, Animal

Reported

Ergosterol docking score (TLR4)−3.318

Donepezil docking score (TLR4)−3.934

Ergosterol MMGBSA ΔG bind−36.9

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