AUG 22, 2026 · JOURNAL ARTICLE
Input-output curves demonstrate motor cortex hyperexcitability associated with cognitive impairment in Alzheimer's disease.
Neurobiology of Aging
A well-designed cross-sectional study with biomarker-confirmed early AD and matched controls, demonstrating a mechanistic link between motor cortical hyperexcitability and cognitive impairment, but limited by cross-sectional design and lack of longitudinal or clinical outcome validation.
Reported
Sample size – early AD63
Sample size – cognitively unimpai…72
Resting motor threshold group dif…p < 0.001