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Rutul Gokalani

Swasthya Diabetes Care

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AUG 12, 2026 · REVIEW

Burden and Risk of Depression in Patients Receiving Semaglutide: A Systematic Review and Meta‐Analysis

Clinical Obesity

Rigorous systematic review and meta-analysis with prespecified protocol (PRISMA 2020) across multiple study types and data sources, reporting clear null findings for depression, anxiety, and suicidal ideation with semaglutide, though high heterogeneity limits certainty.

Strong EvidenceShilanjan Roy Banshi Saboo Anchin Kalia

Reported

Risk ratio for depression1.25

95% CI depression0.95–1.65

I² heterogeneity depression98%

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