JUL 30, 2026 · JOURNAL ARTICLE
Psychotherapy vs antidepressants in heart failure: Impact of adherence.
Journal of Affective Disorders
A rigorous per-protocol analysis of a pragmatic RCT with 416 participants and 1-year follow-up showing a clear, pre-specified outcome (quality of life endpoints) with reported effect sizes and confidence intervals, though limited by secondary analysis design and lack of primary endpoint difference.
Reported
Sample size416
Primary endpoint (PHQ-9 depressiv…no significant difference reported
Mental HRQoL (SF-12v2-MC) at 6 mo…5.22