AUG 14, 2026 · JOURNAL ARTICLE
GSDME mediated pyroptosis drives CCL5 secretion and dictates proteasome inhibitor efficacy in solid tumors
Pharmacological Research
Mechanistic study identifying GSDME-mediated pyroptosis as a determinant of proteasome inhibitor efficacy, supported by multiple tumor models and human correlative data, but lacks prospective clinical trials or hard clinical outcomes.
Study details
DesignPreclinical mechanistic study (in vitro and…
InterventionProteasome inhibitor combinations (Bortezom…
ComparatorControl/vehicle-treated tumors; GSDME-defic…