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Waguih William IsHak

Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA(1); David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Electronic address: Waguih.IsHak@cshs.org.

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JUL 30, 2026 · JOURNAL ARTICLE

Psychotherapy vs antidepressants in heart failure: Impact of adherence.

Journal of Affective Disorders

A rigorous per-protocol analysis of a pragmatic RCT with 416 participants and 1-year follow-up showing a clear, pre-specified outcome (quality of life endpoints) with reported effect sizes and confidence intervals, though limited by secondary analysis design and lack of primary endpoint difference.

Strong EvidenceItai Danovitch Heart Failure Michele A Hamilton

Reported

Sample size416

Primary endpoint (PHQ-9 depressiv…no significant difference reported

Mental HRQoL (SF-12v2-MC) at 6 mo…5.22

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