In vitro mechanistic study establishing a cellular aging model and demonstrating senolytic activity of fisetin in a single-cell system; requires in vivo validation before clinical relevance can be assessed.
Reported
SA-β-gal+ cells (non-stimulated)2.0 (0.7)%
SA-β-gal+ cells (H2O2-stimulated)81.7 (12.1)%
SA-β-gal+ cells (fisetin 24 h)19.1 (5.2)%