JUL 28, 2026 · JOURNAL ARTICLE
BCG vaccine induces distinct metabolic shifts in monocytes in vitro and peripheral blood plasma in vivo: Implications for neonatal trained immunity 2308689
The Journal of Immunology
Mechanistic integration of in vitro and in vivo metabolomics in newborns reveals distinct BCG-induced metabolic signatures that may explain trained immunity, but lacks quantified effect sizes, clinical endpoints, or comparative statistical contrasts.
Reported
In vitro sample size (newborns)10
In vitro sample size (adults)12
In vivo sample size per group (BC…44–50