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Carolin Walter

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AUG 12, 2026 · JOURNAL ARTICLE

fourSynergy: ensemble-based interaction calling on 4C-seq data using gradient-free optimization

Biodata Mining

A methodological study demonstrating an ensemble algorithm for chromatin interaction detection with improved computational performance metrics, but lacking clinical validation, prospective application, or comparison to gold-standard experimental confirmation.

PreliminaryLucas Plagwitz Jonas Dix Sophie-Marie Wind

Reported

F1-score (ensemble)0.31

F1-score (individual tools)0.13

AUPRC (ensemble)0.34

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