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Researcher

Shiyi Zhong

Hubei University

1 development in the corpus

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AUG 13, 2026 · JOURNAL ARTICLE

BifunctionalIonophores for Cuproptosis Activation:Dual Targeting of Copper and Fe–S Protein Homeostasis

Journal of Medicinal Chemistry

Early-stage in vitro mechanistic work demonstrating a novel compound design principle and cellular effects in cancer cells, without clinical trial data or in vivo efficacy validation.

Hypothesis-GeneratingJun Jiang Liuxin Yang Si Qin

Study details

DesignIn vitro chemical design and cellular mecha…

InterventionBifunctional ionophores (HDQ, HDQ-S, HDQ-Ph…

ComparatorElesclomol (clinical copper ionophore) and…

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