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Min Xu

First Affiliated Hospital of Hunan University of Traditional Chinese Medicine

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AUG 9, 2026 · JOURNAL ARTICLE

Systematic Comparison of High‐Fat Diet– and Streptozotocin‐Induced Prediabetic Obese C57BL / 6J Mouse Models: A Sex‐Based Protocol Optimization Study

Diabetes Obesity and Metabolism

Protocol optimization study in animal models comparing five inbred mouse regimens; provides useful characterization for researchers but lacks clinical outcomes, human translation, or definitive evidence for therapeutic testing.

PreliminaryWei Zhang Yang Cao Yangkun Liu

Reported

HFD-STZ-L success rate73.3%

Male glucose/hepatic lipid deteri…Week 12

Female Pre-DM threshold timepoint16 weeks

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