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A narrative review synthesizing preliminary open-label clinical evidence and putative mechanisms without new empirical data; the source itself acknowledges small sample sizes, lack of controlled trials, and unresolved safety and dosing questions, positioning propofol as a candidate for future study rather than an established therapeutic.
Meta-analysis of 16 predominantly single-arm studies (540 patients) reports favorable pooled proportions for sphincter preservation (90%) and R0 resection (98%), but evidence is low-to-moderate certainty without direct RCT comparisons; confirmatory trials needed.