AUG 12, 2026 · JOURNAL ARTICLE
Adipocyte-derived estrogen signaling influences TROP2 expression in ERα-positive breast cancer
Frontiers in Endocrinology
A mechanistic study in cell culture models demonstrating that adipocyte-derived estrogen reduces TROP2 expression and ADC efficacy in ERα-positive breast cancer, supported by correlative in silico and patient cohort data but lacking in vivo validation or clinical outcome evidence.
Reported
Primary experimental approachConditioned media from 3T3-L1 adipocytes ap…
Readouts for TROP2 expressionqRT-PCR and immunoblotting
Estradiol quantification methodELISA in adipocyte conditioned media