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Rongjiang Zhang

Innovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China; School of Mathematics and Statistics, Qilu University of Technology (Shandong Academy of Sciences), Jinan 25035

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AUG 26, 2026 · JOURNAL ARTICLE

Non-linear association of blood urea nitrogen with low cognitive performance: Translational evidence from murine models and human population analysis.

Experimental Neurology

Cross-species translational study with human observational data showing a novel non-linear association, but limited by lack of prospective design, mechanistic uncertainty, and authors' own call for validation in independent cohorts.

PreliminaryYing Yu Alzheimer Disease Xiaorui Cheng

Reported

Sample size (human cohort)3435

BUN threshold for risk plateauapproximately 12 mg/dL

Association direction (BUN and lo…inverse (significant)

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