AUG 11, 2026 · JOURNAL ARTICLE
A Hybrid Lifestyle Program and Metabolic Health in Adults With Obesity
JAMA Network Open
A randomized trial of reasonable design that failed its primary endpoint in intention-to-treat analysis but showed metabolic benefits in per-protocol subgroups; results suggest potential in adherent participants but require confirmation in larger, longer studies.
Reported
Sample size200
Primary endpoint: ≥5% weight loss…20.6% (20/97)
Primary endpoint: ≥5% weight loss…15.5% (16/103)