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Yanelda García

1 development in the corpus

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AUG 18, 2026 · JOURNAL ARTICLE

Regulation of Extracellular HMGB-1 Alarmin Levels by CIGB-300 Anticancer Peptide In Vitro and In Vivo

Kinases and Phosphatases

Early mechanistic work combining in vitro cell lines with exploratory Phase I data, investigating a biomarker association rather than clinical outcomes; needs confirmatory studies in larger patient cohorts.

PreliminaryDania M. Vázquez Daylen Aguilar-Noriega Silvio E. Perea

Reported

p-value for HMGB-1 upregulation a…p = 0.01

Fold-change threshold for associa…≥2

Phase I patients with plasma HMGB…4 of 7

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