AUG 17, 2026 · JOURNAL ARTICLE
DNA methylation modulation by 5-Azacytidine regulates EMT markers and reduces invasiveness in docetaxel-resistant prostate cancer cells
Scientific Reports
In vitro mechanistic study in cancer cell lines demonstrating that DNMT1 inhibition modulates EMT markers and reduces invasiveness in docetaxel-resistant prostate cancer, but lacks in vivo validation, clinical endpoints, or human data.
Reported
Invasion reduction (DU145-DR)p<0.05 at 1 µM; p<0.0001 at 2 µM
Invasion reduction (PC3-DR)p<0.0001 at 1 µM; p<0.01 at 2 µM
CDH1 upregulation (DU145-DR)p<0.05