AUG 17, 2026 · JOURNAL ARTICLE
Dioscin Reverses Drug Resistance via AKT/GSK3β‐mediated P‐gp Degradation and EMT Inhibition
Drug Development Research
Mechanistic study in resistant cell lines with in vivo xenograft validation, but no clinical trial data, no comparative chemotherapy arm, and no human efficacy or safety evidence.
Reported
Study systemPaclitaxel-resistant TE-1/PTX and HeLa/PTX…
Primary mechanismDirect Dio-AKT1 interaction verified by net…
Pathway targetAKT/GSK3β-dependent ubiquitin-proteasomal P…