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Jan Terje Andersen

Oslo University Hospital

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AUG 14, 2026 · JOURNAL ARTICLE

Fusion of IgG antibodies to albumin inhibits transport across the placenta

Science Immunology

Sound preclinical and ex vivo mechanistic work demonstrating a proof-of-concept approach to reduce placental IgG transport, with a functional disease model showing attenuation of fetal pathology, but requiring clinical translation.

PromisingKine Marita Knudsen Sand Hana J. Al Khabbaz Simone Mester

Study details

DesignPreclinical mechanistic study: mouse models…

InterventionFusion of IgG or Fab fragments to albumin (…

ComparatorNative IgG; albumin alone in transport assa…

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