Drug or technology

Antidepressant Therapy

2 developments in the corpus

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AUG 7, 2026 · INTERVENTIONAL STUDY

Metformin as Adjunct Therapy in Depression-obesity Comorbidity: Clinical and Genetic Evaluation

ClinicalTrials.gov

This is a clinical trial registry record describing a planned interventional study with no results posted; enrollment is ongoing and no outcome data are available for evaluation.

PreliminaryMetformin Overweight Or Obesity NCT07654179

Reported

Estimated enrollment200

Primary outcome measure 1Change in Severity of the depression, 1 mon…

Primary outcome measure 2Change in BMI, 3 months

JUL 30, 2026 · JOURNAL ARTICLE

Psychotherapy vs antidepressants in heart failure: Impact of adherence.

Journal of Affective Disorders

A rigorous per-protocol analysis of a pragmatic RCT with 416 participants and 1-year follow-up showing a clear, pre-specified outcome (quality of life endpoints) with reported effect sizes and confidence intervals, though limited by secondary analysis design and lack of primary endpoint difference.

Strong EvidenceItai Danovitch Heart Failure Michele A Hamilton

Reported

Sample size416

Primary endpoint (PHQ-9 depressiv…no significant difference reported

Mental HRQoL (SF-12v2-MC) at 6 mo…5.22