Sen Zhang

AUG 24, 2026 · JOURNAL ARTICLE

Clinical validation of KIF11 overexpression in colorectal cancer and its potential association with the antitumor effects of nitidine chloride

Hereditas

This is a mechanistic discovery study combining computational prediction, molecular profiling, and cell-based experiments that propose KIF11 as a target and NC as a candidate agent, but lacks clinical efficacy data, adequate in vivo validation, or direct evidence of NC's antitumor effect in animal models.

AUG 18, 2026 · JOURNAL ARTICLE

A multicohort, biomarker-driven phase 2 trial of personalized total neoadjuvant therapy with targeted agents for high-risk rectal cancer (The TRAINER study)

Signal Transduction and Targeted Therapy

A single-center phase 2 trial with a meaningful primary endpoint (40% complete response) and acceptable safety, but limited by lack of control group, modest sample size, and single-center design requiring confirmation in larger studies.