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Stevie van der Mierden

The Netherlands Cancer Institute

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SEP 10, 2026 · REVIEW

Intra- and intertumoral discordance of Claudin-18.2: a systematic review and meta-analysis

ESMO Gastrointestinal Oncology

Rigorous meta-analysis of 25 studies with adequate pooled sample sizes quantifies clinically meaningful spatial heterogeneity in Claudin-18.2 expression, with clear implications for specimen selection in targeted therapy decisions.

Strong EvidenceZuhir Bodalal D.I.R. Sánchez L.L. Kodach

Reported

Intratumoral discordance rate (po…35.8%

Intratumoral discordance 95% CI20.5–54.7%

Intratumoral I²94.3%

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